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Long-range side-chain–main-chain interactions play crucial roles in stabilizing the (βα)(8) barrel motif of the alpha subunit of tryptophan synthase
The role of hither-to-fore unrecognized long-range hydrogen bonds between main-chain amide hydrogens and polar side chains on the stability of a well-studied (βα)(8), TIM barrel protein, the alpha subunit of tryptophan synthase (αTS), was probed by mutational analysis. The F19–D46 and I97–D124 hydro...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2206699/ https://ncbi.nlm.nih.gov/pubmed/17586773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062704507 |
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