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Long-range side-chain–main-chain interactions play crucial roles in stabilizing the (βα)(8) barrel motif of the alpha subunit of tryptophan synthase

The role of hither-to-fore unrecognized long-range hydrogen bonds between main-chain amide hydrogens and polar side chains on the stability of a well-studied (βα)(8), TIM barrel protein, the alpha subunit of tryptophan synthase (αTS), was probed by mutational analysis. The F19–D46 and I97–D124 hydro...

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Библиографические подробности
Главные авторы: Yang, Xiaoyan, Vadrevu, Ramakrishna, Wu, Ying, Matthews, C. Robert
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2007
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206699/
https://ncbi.nlm.nih.gov/pubmed/17586773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062704507
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