A tightly-packed hydrophobic cluster directs the formation of an off-pathway sub-millisecond folding intermediate in the alpha subunit of tryptophan synthase, a TIM barrel protein

Protein misfolding is now recognized as playing a crucial role in both normal and pathogenic folding reactions. An interesting example of misfolding at the earliest state of a natural folding reaction is provided by the alpha subunit of tryptophan synthase, a (β/α)(8) TIM barrel protein. The molecul...

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Hlavní autoři: Wu, Ying, Vadrevu, Ramakrishna, Kathuria, Sagar, Yang, Xiaoyan, Matthews, C. Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1894912/
https://ncbi.nlm.nih.gov/pubmed/17222865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.12.005
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