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The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro.

Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC)...

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Sparad:
I publikationen:Antimicrob Agents Chemother
Huvudupphov: Coates, J A, Cammack, N, Jenkinson, H J, Mutton, I M, Pearson, B A, Storer, R, Cameron, J M, Penn, C R
Materialtyp: Artigo
Språk:Inglês
Utgiven: American Society for Microbiology (ASM) 1992
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189255/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1590690/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.1.202
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