The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro.

Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-en...

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Detalhes bibliográficos
Main Authors: Coates, J A, Cammack, N, Jenkinson, H J, Mutton, I M, Pearson, B A, Storer, R, Cameron, J M, Penn, C R
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC189255/
https://ncbi.nlm.nih.gov/pubmed/1590690
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