Effects of (-)-2'-deoxy-3'-thiacytidine (3TC) 5'-triphosphate on human immunodeficiency virus reverse transcriptase and mammalian DNA polymerases alpha, beta, and gamma.

Lignende værker

• The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro.
  af: Coates, J A, et al.
  Udgivet: (1992)
• Azidothymidine triphosphate is an inhibitor of both human immunodeficiency virus type 1 reverse transcriptase and DNA polymerase gamma.
  af: König, H, et al.
  Udgivet: (1989)
• Increased polymerase fidelity of the 3TC-resistant variants of HIV-1 reverse transcriptase.
  af: Oude Essink, B B, et al.
  Udgivet: (1997)
• High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase.
  af: Boucher, C A, et al.
  Udgivet: (1993)
• Increased activation of the combination of 3'-azido-3'-deoxythymidine and 2'-deoxy-3'-thiacytidine in the presence of hydroxyurea.
  af: Palmer, S, et al.
  Udgivet: (1997)