Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes.

Four different isomers of 2',3'-dideoxy-3'-thiacytidine [beta-DL-(+-)-BCH-189] were evaluated in primary human lymphocytes infected with human immunodeficiency virus type 1. The beta-L-(-) isomer was the most potent enantiomer, with a median effective concentration of 1.8 nM and no di...

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Detalhes bibliográficos
Main Authors: Schinazi, R F, Chu, C K, Peck, A, McMillan, A, Mathis, R, Cannon, D, Jeong, L S, Beach, J W, Choi, W B, Yeola, S
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC190578/
https://ncbi.nlm.nih.gov/pubmed/1320365
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