Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes.

Four different isomers of 2',3'-dideoxy-3'-thiacytidine [beta-DL-(+-)-BCH-189] were evaluated in primary human lymphocytes infected with human immunodeficiency virus type 1. The beta-L-(-) isomer was the most potent enantiomer, with a median effective concentration of 1.8 nM and no discernible cytot...

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Библиографические подробности

Опубликовано в::	Antimicrob Agents Chemother
Главные авторы:	Schinazi, R F, Chu, C K, Peck, A, McMillan, A, Mathis, R, Cannon, D, Jeong, L S, Beach, J W, Choi, W B, Yeola, S
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1992
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190578/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1320365/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.3.672
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