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Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2'-deoxy-3'-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog.

We describe a novel nucleoside analog, 2'-deoxy-3'-thiacytidine (BCH-189), in which the 3' carbon of the ribose ring of 2'-deoxycytidine has been replaced by a sulfur atom. In MT-4 T cells, this compound had significant time- and dose-dependent antiviral activity against five dif...

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Detalhes bibliográficos
Main Authors: Soudeyns, H, Yao, X I, Gao, Q, Belleau, B, Kraus, J L, Nguyen-Ba, N, Spira, B, Wainberg, M A
Formato: Artigo
Idioma:Inglês
Publicado em: 1991
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC245177/
https://ncbi.nlm.nih.gov/pubmed/1929298
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