Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2'-deoxy-3'-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog.

We describe a novel nucleoside analog, 2'-deoxy-3'-thiacytidine (BCH-189), in which the 3' carbon of the ribose ring of 2'-deoxycytidine has been replaced by a sulfur atom. In MT-4 T cells, this compound had significant time- and dose-dependent antiviral activity against five different strains of hu...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Soudeyns, H, Yao, X I, Gao, Q, Belleau, B, Kraus, J L, Nguyen-Ba, N, Spira, B, Wainberg, M A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245177/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1929298/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.7.1386
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