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Stepwise Exposure of Staphylococcus aureus to Pleuromutilins Is Associated with Stepwise Acquisition of Mutations in rplC and Minimally Affects Susceptibility to Retapamulin

To assess their effects on susceptibility to retapamulin in Staphylococcus aureus, first-, second-, and third-step mutants with elevated MICs to tiamulin and other investigational pleuromutilin compounds were isolated and characterized through exposure to high drug concentrations. All first- and sec...

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Detalles Bibliográficos
Main Authors: Gentry, Daniel R., Rittenhouse, Stephen F., McCloskey, Lynn, Holmes, David J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891380/
https://ncbi.nlm.nih.gov/pubmed/17404009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01066-06
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