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Stepwise Exposure of Staphylococcus aureus to Pleuromutilins Is Associated with Stepwise Acquisition of Mutations in rplC and Minimally Affects Susceptibility to Retapamulin

To assess their effects on susceptibility to retapamulin in Staphylococcus aureus, first-, second-, and third-step mutants with elevated MICs to tiamulin and other investigational pleuromutilin compounds were isolated and characterized through exposure to high drug concentrations. All first- and sec...

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Main Authors: Gentry, Daniel R., Rittenhouse, Stephen F., McCloskey, Lynn, Holmes, David J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2007
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891380/
https://ncbi.nlm.nih.gov/pubmed/17404009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01066-06
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