Unraveling the Metabolic Routes of Retapamulin: Insights into Drug Development of Pleuromutilins

Retapamulin, a semisynthetic pleuromutilin derivative, is exclusively used for the topical short-term medication of impetigo and staphylococcal infections. In the present study, we report that retapamulin is adequately and rapidly metabolized in vitro via various metabolic pathways, such as hydroxyl...

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Bibliografiska uppgifter
I publikationen:Antimicrob Agents Chemother
Huvudupphovsmän: Sun, Feifei, Zhang, Huiyan, Gonzales, Gerard Bryan, Zhou, Jinhui, Li, Yi, Zhang, Jinzhen, Jin, Yue, Wang, Zhanhui, Li, Yanshen, Cao, Xingyuan, Zhang, Suxia, Yang, Shupeng
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2018
Ämnen:
Pharmacology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913982/
https://ncbi.nlm.nih.gov/pubmed/29358298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02388-17
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