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The selection of acceptable protein mutations

We have determined the general constraints that govern sequence divergence in proteins that retain entirely, or very largely, the same structure and function. To do this we collected data from three different groups of orthologous sequences: those found in humans and mice, in humans and chickens, an...

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Hlavní autoři: Sasidharan, Rajkumar, Chothia, Cyrus
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1891269/
https://ncbi.nlm.nih.gov/pubmed/17540730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703737104
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