Mediator protein mutations that selectively abolish activated transcription

Deletion of any one of three subunits of the yeast Mediator of transcriptional regulation, Med2, Pgd1 (Hrs1), and Sin4, abolished activation by Gal4–VP16 in vitro. By contrast, other Mediator functions, stimulation of basal transcription and of TFIIH kinase activity, were unaffected. A different but...

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Bibliografiske detaljer
Main Authors: Myers, Lawrence C., Gustafsson, Claes M., Hayashibara, Kathleen C., Brown, Patrick O., Kornberg, Roger D.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC15094/
https://ncbi.nlm.nih.gov/pubmed/9874773
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