Preventing fibril formation of a protein by selective mutation

The origins of formation of an intermediate state involved in amyloid formation and ways to prevent it are illustrated with the example of the Formin binding protein 28 (FBP28) WW domain, which folds with biphasic kinetics. Molecular dynamics of protein folding trajectories are used to examine local...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Maisuradze, Gia G., Medina, Jordi, Kachlishvili, Khatuna, Krupa, Pawel, Mozolewska, Magdalena A., Martin-Malpartida, Pau, Maisuradze, Luka, Macias, Maria J., Scheraga, Harold A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640778/
https://ncbi.nlm.nih.gov/pubmed/26483482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518298112
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