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Elucidating important sites and the mechanism for amyloid fibril formation by coarse-grained molecular dynamics
Fibrils formed by the β-amyloid (Aβ) peptide play a central role in the development of Alzheimer’s disease. In this study, the principles governing their growth and stability are investigated by analyzing canonical and replica-exchange molecular dynamics trajectories of Aβ((9–40)) fibrils. In partic...
Gorde:
| Argitaratua izan da: | ACS Chem Neurosci |
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| Egile Nagusiak: | , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2016
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5245180/ https://ncbi.nlm.nih.gov/pubmed/28095675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00331 |
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