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Simulation of the opening and closing of Hsp70 chaperones by coarse-grained molecular dynamics
Heat-shock proteins 70 (Hsp70s) are key molecular chaperones which assist in the folding and refolding/disaggregation of proteins. Hsp70s, which consist of a nucleotide-binding domain (NBD, consisting of NBD-I and NBD-II subdomains) and a substrate-binding domain [SBD, further split into the β-sheet...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3380372/ https://ncbi.nlm.nih.gov/pubmed/22737044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct200680g |
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