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Simulation of the opening and closing of Hsp70 chaperones by coarse-grained molecular dynamics

Heat-shock proteins 70 (Hsp70s) are key molecular chaperones which assist in the folding and refolding/disaggregation of proteins. Hsp70s, which consist of a nucleotide-binding domain (NBD, consisting of NBD-I and NBD-II subdomains) and a substrate-binding domain [SBD, further split into the β-sheet...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Gołaś, Ewa, Maisuradze, Gia G., Senet, Patrick, Ołdziej, Stanisław, Czaplewski, Cezary, Scheraga, Harold A., Liwo, Adam
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2012
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380372/
https://ncbi.nlm.nih.gov/pubmed/22737044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct200680g
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