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Development of autoimmunity in mice lacking DNA topoisomerase 3β

Mice lacking DNA topoisomerase 3β are predisposed to a shortened lifespan, infertility, and lesions in multiple organs resulting from inflammatory responses. Examination of the immune system of 6- and 52-week-old top3β(−/−) mice revealed no significant aberrations in their central and peripheral tol...

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Detalhes bibliográficos
Main Authors: Kwan, Kelvin Y., Greenwald, Rebecca J., Mohanty, Subhasis, Sharpe, Arlene H., Shaw, Albert C., Wang, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890479/
https://ncbi.nlm.nih.gov/pubmed/17517607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703587104
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