Mice lacking DNA topoisomerase IIIβ develop to maturity but show a reduced mean lifespan
Targeted gene disruption in the murine TOP3β gene-encoding DNA topoisomerase IIIβ was carried out. In contrast to the embryonic lethality of mutant mice lacking DNA topoisomerase IIIα, top3β(−/−) nulls are viable and grow to maturity with no apparent defects. Mice lacking DNA topoisomerase IIIβ have...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33279/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11331780/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.101132498 |
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