Mammalian DNA topoisomerase IIIα is essential in early embryogenesis
Targeted disruption of the mouse TOP3α gene encoding DNA topoisomerase IIIα was carried out to study the physiological functions of the mammalian type IA DNA topoisomerase. Whereas heterozygous top3α(+/−) mutant mice were found to resemble phenotypically their TOP3α(+/+) litermates, no viable top3α(...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18654/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9448276/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.3.1010 |
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