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Mammalian DNA topoisomerase IIIα is essential in early embryogenesis

Targeted disruption of the mouse TOP3α gene encoding DNA topoisomerase IIIα was carried out to study the physiological functions of the mammalian type IA DNA topoisomerase. Whereas heterozygous top3α(+/−) mutant mice were found to resemble phenotypically their TOP3α(+/+) litermates, no viable top3α(...

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Detalhes bibliográficos
Main Authors: Li, Wei, Wang, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18654/
https://ncbi.nlm.nih.gov/pubmed/9448276
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