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Macrophage Entry Mediated by HIV Envs from Brain and Lymphoid Tissues is Determined by the Capacity to use Low CD4 Levels and Overall Efficiency of Fusion
HIV infects macrophages and microglia in the central nervous system (CNS), which express lower levels of CD4 than CD4+ T cells in peripheral blood. To investigate mechanisms of HIV neurotropism, full-length env genes were cloned from autopsy brain and lymphoid tissues from 4 AIDS patients with HIV-a...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1890014/ https://ncbi.nlm.nih.gov/pubmed/17084877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2006.09.036 |
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