Loss of the N-linked glycosylation site at position 386 in the HIV envelope V4 region enhances macrophage tropism and is associated with dementia

HIV infects macrophages and microglia in the central nervous system (CNS). Mechanisms that enhance HIV macrophage/microglial tropism are not well understood. Here, we identify an HIV Env variant in the V4 region of gp120, Asp 386 (D386), that eliminates an N-linked glycosylation site at position 386...

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Detalhes bibliográficos
Main Authors: Dunfee, Rebecca L., Thomas, Elaine R., Wang, Jianbin, Kunstman, Kevin, Wolinsky, Steven M., Gabuzda, Dana
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2201988/
https://ncbi.nlm.nih.gov/pubmed/17599380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.05.029
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