Arginine insertion and loss of N-linked glycosylation site in HIV-1 envelope V3 region confer CXCR4-tropism

The third variable region (V3) of HIV-1 envelope glycoprotein gp120 plays a key role in determination of viral coreceptor usage (tropism). However, which combinations of mutations in V3 confer a tropism shift is still unclear. A unique pattern of mutations in antiretroviral therapy-naive HIV-1 patie...

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Detalhes bibliográficos
Main Authors: Tsuchiya, Kiyoto, Ode, Hirotaka, Hayashida, Tsunefusa, Kakizawa, Junko, Sato, Hironori, Oka, Shinichi, Gatanaga, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737504/
https://ncbi.nlm.nih.gov/pubmed/23925152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02389
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