Combination of V106I and V179D Polymorphic Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Resistance to Efavirenz and Nevirapine but Not Etravirine

Etravirine (ETV) is a second-generation nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI) introduced recently for salvage antiretroviral treatment after the emergence of NNRTI-resistant human immunodeficiency virus type 1 (HIV-1). Following its introduction, two naturally occurring mutation...

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Bibliographic Details
Main Authors: Gatanaga, Hiroyuki, Ode, Hirotaka, Hachiya, Atsuko, Hayashida, Tsunefusa, Sato, Hironori, Oka, Shinichi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849364/
https://ncbi.nlm.nih.gov/pubmed/20124001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01480-09
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