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The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia
HIV infects tissue macrophages and brain microglia, which express lower levels of CD4 and CCR5 than CD4(+) T cells in peripheral blood. Mechanisms that enhance HIV tropism for macrophages in the CNS and other tissues are not well understood. Here, we identify an HIV envelope glycoprotein (Env) varia...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1586182/ https://ncbi.nlm.nih.gov/pubmed/17015824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605513103 |
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