The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia

HIV infects tissue macrophages and brain microglia, which express lower levels of CD4 and CCR5 than CD4(+) T cells in peripheral blood. Mechanisms that enhance HIV tropism for macrophages in the CNS and other tissues are not well understood. Here, we identify an HIV envelope glycoprotein (Env) varia...

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Bibliographische Detailangaben
Hauptverfasser: Dunfee, Rebecca L., Thomas, Elaine R., Gorry, Paul R., Wang, Jianbin, Taylor, Joann, Kunstman, Kevin, Wolinsky, Steven M., Gabuzda, Dana
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1586182/
https://ncbi.nlm.nih.gov/pubmed/17015824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605513103
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