The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia

HIV infects tissue macrophages and brain microglia, which express lower levels of CD4 and CCR5 than CD4(+) T cells in peripheral blood. Mechanisms that enhance HIV tropism for macrophages in the CNS and other tissues are not well understood. Here, we identify an HIV envelope glycoprotein (Env) varia...

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Detalhes bibliográficos
Main Authors: Dunfee, Rebecca L., Thomas, Elaine R., Gorry, Paul R., Wang, Jianbin, Taylor, Joann, Kunstman, Kevin, Wolinsky, Steven M., Gabuzda, Dana
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1586182/
https://ncbi.nlm.nih.gov/pubmed/17015824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605513103
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