The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia

HIV infects tissue macrophages and brain microglia, which express lower levels of CD4 and CCR5 than CD4(+) T cells in peripheral blood. Mechanisms that enhance HIV tropism for macrophages in the CNS and other tissues are not well understood. Here, we identify an HIV envelope glycoprotein (Env) varia...

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Main Authors: Dunfee, Rebecca L., Thomas, Elaine R., Gorry, Paul R., Wang, Jianbin, Taylor, Joann, Kunstman, Kevin, Wolinsky, Steven M., Gabuzda, Dana
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1586182/
https://ncbi.nlm.nih.gov/pubmed/17015824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605513103
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