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Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5
Macrophages express low levels of the CD4 receptor compared to T-cells. Macrophagetropic HIV strains replicating in brain of untreated patients with HIV-associated dementia (HAD) express Envs that adapted to overcome this restriction through mechanisms that are poorly understood. Here, bioinformatic...
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| Publicado no: | Virology |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4437837/ https://ncbi.nlm.nih.gov/pubmed/25797607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2015.01.032 |
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