Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5

Macrophages express low levels of the CD4 receptor compared to T-cells. Macrophagetropic HIV strains replicating in brain of untreated patients with HIV-associated dementia (HAD) express Envs that adapted to overcome this restriction through mechanisms that are poorly understood. Here, bioinformatic...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Virology
Egile Nagusiak: Mefford, Megan E., Kunstman, Kevin, Wolinsky, Steven M., Gabuzda, Dana
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437837/
https://ncbi.nlm.nih.gov/pubmed/25797607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2015.01.032
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak