Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5

Macrophages express low levels of the CD4 receptor compared to T-cells. Macrophagetropic HIV strains replicating in brain of untreated patients with HIV-associated dementia (HAD) express Envs that adapted to overcome this restriction through mechanisms that are poorly understood. Here, bioinformatic...

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Vydáno v:Virology
Hlavní autoři: Mefford, Megan E., Kunstman, Kevin, Wolinsky, Steven M., Gabuzda, Dana
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4437837/
https://ncbi.nlm.nih.gov/pubmed/25797607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2015.01.032
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