Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity

Regulation of biological processes often involves phosphorylation of intrinsically disordered protein regions, thereby modulating protein interactions. Initiation of DNA replication in yeast requires elimination of the cyclin-dependent kinase inhibitor Sic1 via the SCF(Cdc4) ubiquitin ligase. Intrig...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Borg, Mikael, Mittag, Tanja, Pawson, Tony, Tyers, Mike, Forman-Kay, Julie D., Chan, Hue Sun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2007
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1887549/
https://ncbi.nlm.nih.gov/pubmed/17522259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702580104
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