Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity

Regulation of biological processes often involves phosphorylation of intrinsically disordered protein regions, thereby modulating protein interactions. Initiation of DNA replication in yeast requires elimination of the cyclin-dependent kinase inhibitor Sic1 via the SCF(Cdc4) ubiquitin ligase. Intrig...

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Bibliographic Details
Main Authors: Borg, Mikael, Mittag, Tanja, Pawson, Tony, Tyers, Mike, Forman-Kay, Julie D., Chan, Hue Sun
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1887549/
https://ncbi.nlm.nih.gov/pubmed/17522259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702580104
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