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Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity
Regulation of biological processes often involves phosphorylation of intrinsically disordered protein regions, thereby modulating protein interactions. Initiation of DNA replication in yeast requires elimination of the cyclin-dependent kinase inhibitor Sic1 via the SCF(Cdc4) ubiquitin ligase. Intrig...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1887549/ https://ncbi.nlm.nih.gov/pubmed/17522259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702580104 |
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