Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity

Regulation of biological processes often involves phosphorylation of intrinsically disordered protein regions, thereby modulating protein interactions. Initiation of DNA replication in yeast requires elimination of the cyclin-dependent kinase inhibitor Sic1 via the SCF(Cdc4) ubiquitin ligase. Intrig...

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Hlavní autoři: Borg, Mikael, Mittag, Tanja, Pawson, Tony, Tyers, Mike, Forman-Kay, Julie D., Chan, Hue Sun
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1887549/
https://ncbi.nlm.nih.gov/pubmed/17522259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702580104
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