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Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor.

Inhibitors of the human immunodeficiency virus protease represent a promising new class of antiretroviral drugs for the treatment of AIDS. We now report the in vitro selection of viral variants with decreased sensitivity to a symmetry-based protease inhibitor, ABT-538, currently being tested in clin...

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Bibliografische gegevens
Hoofdauteurs: Markowitz, M, Mo, H, Kempf, D J, Norbeck, D W, Bhat, T N, Erickson, J W, Ho, D D
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1995
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC188631/
https://ncbi.nlm.nih.gov/pubmed/7815532
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