Protein structure-based design of potent orally bioavailable, nonpeptide inhibitors of human immunodeficiency virus protease.

A class of potent nonpeptidic inhibitors of human immunodeficiency virus protease has been designed by using the three-dimensional structure of the enzyme as a guide. By employing iterative protein cocrystal structure analysis, design, and synthesis the binding affinity of the lead compound was incr...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Reich, S H, Melnick, M, Davies, J F, Appelt, K, Lewis, K K, Fuhry, M A, Pino, M, Trippe, A J, Nguyen, D, Dawson, H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42153/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7724556/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.8.3298
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