Protein structure-based design of potent orally bioavailable, nonpeptide inhibitors of human immunodeficiency virus protease.

A class of potent nonpeptidic inhibitors of human immunodeficiency virus protease has been designed by using the three-dimensional structure of the enzyme as a guide. By employing iterative protein cocrystal structure analysis, design, and synthesis the binding affinity of the lead compound was incr...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Reich, S H, Melnick, M, Davies, J F, Appelt, K, Lewis, K K, Fuhry, M A, Pino, M, Trippe, A J, Nguyen, D, Dawson, H
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC42153/
https://ncbi.nlm.nih.gov/pubmed/7724556
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados