Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor.

Inhibitors of the human immunodeficiency virus protease represent a promising new class of antiretroviral drugs for the treatment of AIDS. We now report the in vitro selection of viral variants with decreased sensitivity to a symmetry-based protease inhibitor, ABT-538, currently being tested in clin...

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Pubblicato in:	J Virol
Autori principali:	Markowitz, M, Mo, H, Kempf, D J, Norbeck, D W, Bhat, T N, Erickson, J W, Ho, D D
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC188631/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7815532/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.2.701-706.1995
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