ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease

The valine at position 82 (Val 82) in the active site of the human immunodeficiency virus (HIV) protease mutates in response to therapy with the protease inhibitor ritonavir. By using the X-ray crystal structure of the complex of HIV protease and ritonavir, the potent protease inhibitor ABT-378, whi...

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Hlavní autoři: Sham, Hing L., Kempf, Dale J., Molla, Akhteruzammen, Marsh, Kennan C., Kumar, Gondi N., Chen, Chih-Ming, Kati, Warren, Stewart, Kent, Lal, Ritu, Hsu, Ann, Betebenner, David, Korneyeva, Marina, Vasavanonda, Sudthida, McDonald, Edith, Saldivar, Ayda, Wideburg, Norm, Chen, Xiaoqi, Niu, Ping, Park, Chang, Jayanti, Venkata, Grabowski, Brian, Granneman, G. Richard, Sun, Eugene, Japour, Anthony J., Leonard, John M., Plattner, Jacob J., Norbeck, Daniel W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1998
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC106025/
https://ncbi.nlm.nih.gov/pubmed/9835517
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