ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease

The valine at position 82 (Val 82) in the active site of the human immunodeficiency virus (HIV) protease mutates in response to therapy with the protease inhibitor ritonavir. By using the X-ray crystal structure of the complex of HIV protease and ritonavir, the potent protease inhibitor ABT-378, whi...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Sham, Hing L., Kempf, Dale J., Molla, Akhteruzammen, Marsh, Kennan C., Kumar, Gondi N., Chen, Chih-Ming, Kati, Warren, Stewart, Kent, Lal, Ritu, Hsu, Ann, Betebenner, David, Korneyeva, Marina, Vasavanonda, Sudthida, McDonald, Edith, Saldivar, Ayda, Wideburg, Norm, Chen, Xiaoqi, Niu, Ping, Park, Chang, Jayanti, Venkata, Grabowski, Brian, Granneman, G. Richard, Sun, Eugene, Japour, Anthony J., Leonard, John M., Plattner, Jacob J., Norbeck, Daniel W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC106025/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9835517/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.12.3218
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