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ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease

The valine at position 82 (Val 82) in the active site of the human immunodeficiency virus (HIV) protease mutates in response to therapy with the protease inhibitor ritonavir. By using the X-ray crystal structure of the complex of HIV protease and ritonavir, the potent protease inhibitor ABT-378, whi...

Cur síos iomlán

Sábháilte in:
Foilsithe in:Antimicrob Agents Chemother
Príomhchruthaitheoirí: Sham, Hing L., Kempf, Dale J., Molla, Akhteruzammen, Marsh, Kennan C., Kumar, Gondi N., Chen, Chih-Ming, Kati, Warren, Stewart, Kent, Lal, Ritu, Hsu, Ann, Betebenner, David, Korneyeva, Marina, Vasavanonda, Sudthida, McDonald, Edith, Saldivar, Ayda, Wideburg, Norm, Chen, Xiaoqi, Niu, Ping, Park, Chang, Jayanti, Venkata, Grabowski, Brian, Granneman, G. Richard, Sun, Eugene, Japour, Anthony J., Leonard, John M., Plattner, Jacob J., Norbeck, Daniel W.
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: American Society for Microbiology (ASM) 1998
Ábhair:
Antiviral Agents
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC106025/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9835517/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.12.3218
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