ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease

The valine at position 82 (Val 82) in the active site of the human immunodeficiency virus (HIV) protease mutates in response to therapy with the protease inhibitor ritonavir. By using the X-ray crystal structure of the complex of HIV protease and ritonavir, the potent protease inhibitor ABT-378, whi...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Sham, Hing L., Kempf, Dale J., Molla, Akhteruzammen, Marsh, Kennan C., Kumar, Gondi N., Chen, Chih-Ming, Kati, Warren, Stewart, Kent, Lal, Ritu, Hsu, Ann, Betebenner, David, Korneyeva, Marina, Vasavanonda, Sudthida, McDonald, Edith, Saldivar, Ayda, Wideburg, Norm, Chen, Xiaoqi, Niu, Ping, Park, Chang, Jayanti, Venkata, Grabowski, Brian, Granneman, G. Richard, Sun, Eugene, Japour, Anthony J., Leonard, John M., Plattner, Jacob J., Norbeck, Daniel W.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1998
Fag:	Antiviral Agents
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC106025/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9835517/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.12.3218
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