Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.

Coadministration with the human immunodeficiency virus (HIV) protease inhibitor ritonavir was investigated as a method for enhancing the levels of other peptidomimetic HIV protease inhibitors in plasma. In rat and human liver microsomes, ritonavir potently inhibited the cytochrome P450 (CYP)-mediate...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Kempf, D J, Marsh, K C, Kumar, G, Rodrigues, A D, Denissen, J F, McDonald, E, Kukulka, M J, Hsu, A, Granneman, G R, Baroldi, P A, Sun, E, Pizzuti, D, Plattner, J J, Norbeck, D W, Leonard, J M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163767/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9056009/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.3.654
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