Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.

Coadministration with the human immunodeficiency virus (HIV) protease inhibitor ritonavir was investigated as a method for enhancing the levels of other peptidomimetic HIV protease inhibitors in plasma. In rat and human liver microsomes, ritonavir potently inhibited the cytochrome P450 (CYP)-mediate...

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Main Authors: Kempf, D J, Marsh, K C, Kumar, G, Rodrigues, A D, Denissen, J F, McDonald, E, Kukulka, M J, Hsu, A, Granneman, G R, Baroldi, P A, Sun, E, Pizzuti, D, Plattner, J J, Norbeck, D W, Leonard, J M
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC163767/
https://ncbi.nlm.nih.gov/pubmed/9056009
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