The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis

Multiple myeloma (MM) evolves from a highly prevalent premalignant condition termed MGUS. The factors underlying the malignant transformation of MGUS are unknown. We report a MGUS/MM phenotype in transgenic mice with Eμ-directed expression of the XBP-1 spliced isoform (XBP-1s), a factor governing un...

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Main Authors: Carrasco, Daniel R., Sukhdeo, Kumar, Protopopova, Marina, Sinha, Raktim, Enos, Miriam, Carrasco, Daniel E., Zheng, Mei, Mani, Mala, Henderson, Joel, Pinkus, Geraldine S., Munshi, Nikhil, Horner, James, Ivanova, Elena V., Protopopov, Alexei, Anderson, Kenneth C., Tonon, Giovanni, DePinho, Ronald A.
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885943/
https://ncbi.nlm.nih.gov/pubmed/17418411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.02.015
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