The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis

Multiple myeloma (MM) evolves from a highly prevalent premalignant condition termed MGUS. The factors underlying the malignant transformation of MGUS are unknown. We report a MGUS/MM phenotype in transgenic mice with Eμ-directed expression of the XBP-1 spliced isoform (XBP-1s), a factor governing un...

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Detaylı Bibliyografya
Asıl Yazarlar: Carrasco, Daniel R., Sukhdeo, Kumar, Protopopova, Marina, Sinha, Raktim, Enos, Miriam, Carrasco, Daniel E., Zheng, Mei, Mani, Mala, Henderson, Joel, Pinkus, Geraldine S., Munshi, Nikhil, Horner, James, Ivanova, Elena V., Protopopov, Alexei, Anderson, Kenneth C., Tonon, Giovanni, DePinho, Ronald A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2007
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885943/
https://ncbi.nlm.nih.gov/pubmed/17418411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.02.015
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