TRIM13 (RFP2) downregulation decreases tumour cell growth in multiple myeloma through inhibition of NF Kappa B pathway and proteasome activity

Multiple myeloma (MM) is an incurable neoplasm caused by proliferation of malignant plasma cells in the bone marrow (BM). MM is characterized frequently by a complete or partial deletion of chromosome 13q14, seen in more than 50% of patients at diagnosis. Within this deleted region the tripartite mo...

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Hauptverfasser: Gatt, Moshe E, Takada, Kohichi, Mani, Mala, Lerner, Mikael, Pick, Marjorie, Hideshima, Teru, Carrasco, Daniel E., Protopopov, Alexei, Ivanova, Elena, Sangfelt, Olle, Grandér, Dan, Barlogie, Bart, Shaughnessy, John D., Anderson, Kenneth C., Carrasco, Daniel R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709857/
https://ncbi.nlm.nih.gov/pubmed/23647456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12365
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