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The human checkpoint sensor Rad9–Rad1–Hus1 interacts with and stimulates NEIL1 glycosylase

The checkpoint protein Rad9/Rad1/Hus1 heterotrimer (the 9-1-1 complex) is structurally similar to the proliferating cell nuclear antigen sliding clamp and has been proposed to sense DNA damage that leads to cell cycle arrest or apoptosis. Human (h) NEIL1 DNA glycosylase, an ortholog of bacterial Nei...

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Autors principals: Guan, Xin, Bai, Haibo, Shi, Guoli, Theriot, Corey A., Hazra, Tapas K., Mitra, Sankar, Lu, A-Lien
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885643/
https://ncbi.nlm.nih.gov/pubmed/17395641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm075
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