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Assessment of the validity of a population pharmacokinetic model for epirubicin

AIMS: The aim of this study was to evaluate a population model for epirubicin clearance using internal and external validation techniques. METHODS: Jackknife samples were used to identify outliers in the population dataset and individuals influencing covariate selection. Sensitivity analyses were pe...

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Hlavní autoři: Ralph, Lorraine D, Sandstrom, Marie, Twelves, Chris, Dobbs, Nicola A, Thomson, Alison H
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885074/
https://ncbi.nlm.nih.gov/pubmed/16842378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02584.x
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