Models for time-varying covariates in population pharmacokinetic-pharmacodynamic analysis

AIM: If appropriately accounted for in a pharmacokinetic (PK)–pharmacodynamic (PD) model, time-varying covariates can provide additional information to that obtained from time-constant covariates. The aim was to present and apply two models applicable to time-varying covariates that capture such add...

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Главные авторы: Wählby, Ulrika, Thomson, Alison H, Milligan, Peter A, Karlsson, Mats O
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Science Inc 2004
Предметы:
Pharmacokinetics/Pharmacodynamics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884602/
https://ncbi.nlm.nih.gov/pubmed/15373929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02170.x
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