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Comparison of stepwise covariate model building strategies in population pharmacokinetic-pharmacodynamic analysis
The aim of this study was to compare 2 stepwise covariate model-building strategies, frequently used in the analysis of pharmacokinetic-pharmacodynamic (PK-PD) data using nonlinear mixed-effects models, with respect to included covariates and predictive performance. In addition, the effects of stepw...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Springer-Verlag
2002
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2751316/ https://ncbi.nlm.nih.gov/pubmed/12645999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/ps040427 |
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