Population pharmacokinetic/pharmacodynamic (PK/PD) modelling of the hypothalamic–pituitary–gonadal axis following treatment with GnRH analogues

AIMS: To develop a population pharmacokinetic/pharmacodynamic (PK/PD) model of the hypothalamic–pituitary–gonadal (HPG) axis describing the changes in luteinizing hormone (LH) and testosterone concentrations following treatment with the gonadotropin-releasing hormone (GnRH) agonist triptorelin and t...

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Detalhes bibliográficos
Main Authors: Tornøe, Christoffer W, Agersø, Henrik, Senderovitz, Thomas, Nielsen, Henrik A, Madsen, Henrik, Karlsson, Mats O, Jonsson, E Niclas
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2007
Assuntos:
Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000597/
https://ncbi.nlm.nih.gov/pubmed/17096678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2006.02820.x
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