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A Fast Method for Testing Covariates in Population PK/PD Models
The development of covariate models within the population modeling program like NONMEM is generally a time-consuming and non-trivial task. In this study, a fast procedure to approximate the change in objective function values of covariate–parameter models is presented and evaluated. The proposed met...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Springer US
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3160160/ https://ncbi.nlm.nih.gov/pubmed/21725709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9289-2 |
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