Carregant...

Assessment of the relative in vivo potency of the hydroxylated metabolite of darifenacin in its ability to decrease salivary flow using pooled population pharmacokinetic–pharmacodynamic data

AIMS: To describe the population pharmacokinetic–pharmacodynamic relationship between darifenacin (UK-88,525) and its hydroxylated metabolite (UK-148,993), and the reduction in salivary flow (SF, a M(3)-mediated response). This enabled an estimation of the in vivo potency of the metabolite to decrea...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Kerbusch, Thomas, Milligan, Peter A, Karlsson, Mats O
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884440/
https://ncbi.nlm.nih.gov/pubmed/14748816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01988.x
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!