Llwytho...

The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone

AIMS: There is considerable unexplained interindividual variability in the methadone dose-effect relationship. The efflux pump P-glycoprotein (P-gp) regulates brain access and intestinal absorption of many drugs. Evidence suggests that methadone is a P-gp substrate in vitro, and P-gp affects methado...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kharasch, Evan D, Hoffer, Christine, Whittington, Dale
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Science Inc 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884496/
https://ncbi.nlm.nih.gov/pubmed/15089813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2003.02053.x
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