Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin–clarithromycin interaction

AIMS: A clinically important interaction between the cardiac glycoside digoxin and the antibiotic clarithromycin has been suggested in earlier reports. The aim of this study was to investigate the extent of the interaction and the relative contribution of different mechanisms. METHODS: In a randomiz...

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Detaylı Bibliyografya
Asıl Yazarlar: Rengelshausen, Jens, Göggelmann, Christoph, Burhenne, Jürgen, Riedel, Klaus-Dieter, Ludwig, Jochen, Weiss, Johanna, Mikus, Gerd, Walter-Sack, Ingeborg, Haefeli, Walter E
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2003
Konular:
Pharmacokinetics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884337/
https://ncbi.nlm.nih.gov/pubmed/12848773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01824.x
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