Clarithromycin substantially increases steady-state bosentan exposure in healthy volunteers

AIMS: The aim of this study was to assess the effect of the cytochrome P450 (CYP) 3A4 and organic anion-transporting polypeptide (OATP) 1B1 inhibitor clarithromycin on the pharmacokinetics of bosentan. We also aimed to evaluate the impact of CYP2C9 and SLCO1B1 (encoding for OATP1B1) genotypes and th...

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Main Authors: Markert, Christoph, Schweizer, Yvonne, Hellwig, Regina, Wirsching, Theresia, Riedel, Klaus-Dieter, Burhenne, Juergen, Weiss, Johanna, Mikus, Gerd, Haefeli, Walter E
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2014
Assuntos:
Pharmacokinetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895355/
https://ncbi.nlm.nih.gov/pubmed/23738582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12177
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