טוען...
Clarithromycin substantially increases steady-state bosentan exposure in healthy volunteers
AIMS: The aim of this study was to assess the effect of the cytochrome P450 (CYP) 3A4 and organic anion-transporting polypeptide (OATP) 1B1 inhibitor clarithromycin on the pharmacokinetics of bosentan. We also aimed to evaluate the impact of CYP2C9 and SLCO1B1 (encoding for OATP1B1) genotypes and th...
שמור ב:
| Main Authors: | , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Blackwell Science Inc
2014
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3895355/ https://ncbi.nlm.nih.gov/pubmed/23738582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12177 |
| תגים: |
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